290647

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 82668..83190 Replicon plasmid 2
Accession NZ_LR890324
Organism Klebsiella pneumoniae isolate INF348-sc-2280170

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag JMW45_RS25625 Protein ID WP_004187019.1
Coordinates 82906..83190 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag JMW45_RS25620 Protein ID WP_004187025.1
Coordinates 82668..82916 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW45_RS25590 80035..80604 - 570 WP_004152117.1 small heat shock protein sHSP20 -
JMW45_RS25595 80639..80920 - 282 WP_013307885.1 helix-turn-helix domain-containing protein -
JMW45_RS25600 81164..81427 - 264 WP_004118208.1 hypothetical protein -
JMW45_RS25605 81442..81705 + 264 WP_004187027.1 transposase -
JMW45_RS25610 81650..81766 + 117 Protein_80 transposase domain-containing protein -
JMW45_RS25615 81954..82378 + 425 Protein_81 IS1 family transposase -
JMW45_RS25620 82668..82916 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
JMW45_RS25625 82906..83190 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW45_RS25630 83206..84561 - 1356 WP_004187017.1 ISNCY family transposase -
JMW45_RS25635 84643..84942 - 300 Protein_85 conjugal transfer protein TraH -
JMW45_RS25640 84940..85423 - 484 Protein_86 hypothetical protein -
JMW45_RS25645 85440..85964 - 525 Protein_87 hypothetical protein -
JMW45_RS25650 87507..87971 + 465 WP_004187010.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..138469 138469
- flank IS/Tn - - 82148..82414 266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T290647 WP_004187019.1 NZ_LR890324:82906-83190 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT290647 WP_004187025.1 NZ_LR890324:82668-82916 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References