Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2556159..2557747 Replicon chromosome
Accession NZ_LR890323
Organism Klebsiella pneumoniae isolate INF348-sc-2280170

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMW45_RS12615 Protein ID WP_023280065.1
Coordinates 2556159..2557481 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW45_RS12620 Protein ID WP_002904790.1
Coordinates 2557481..2557747 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW45_RS12600 2551215..2553716 + 2502 WP_023280067.1 fimbrial biogenesis outer membrane usher protein -
JMW45_RS12605 2553704..2554708 + 1005 WP_023280066.1 type 1 fimbrial protein -
JMW45_RS12610 2554850..2556142 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW45_RS12615 2556159..2557481 - 1323 WP_023280065.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW45_RS12620 2557481..2557747 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW45_RS12625 2558012..2558338 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW45_RS12630 2558335..2558835 - 501 WP_023280064.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW45_RS12635 2558813..2560192 - 1380 WP_023280063.1 purine permease -
JMW45_RS12640 2560538..2561692 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW45_RS12645 2561673..2562596 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49137.45 Da        Isoelectric Point: 7.5357

>T290640 WP_023280065.1 NZ_LR890323:c2557481-2556159 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPIDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290640 WP_002904790.1 NZ_LR890323:c2557747-2557481 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References