Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 15856..16381 Replicon plasmid 3
Accession NZ_LR890319
Organism Klebsiella pneumoniae isolate INF215-sc-2280087

Toxin (Protein)


Gene name ccdB Uniprot ID A0A9E1GGX2
Locus tag JMX39_RS26650 Protein ID WP_016946795.1
Coordinates 16076..16381 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A9E1GDP8
Locus tag JMX39_RS26645 Protein ID WP_004197642.1
Coordinates 15856..16074 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX39_RS26635 13538..14566 - 1029 WP_001568023.1 Abi family protein -
JMX39_RS26640 14707..15276 - 570 WP_016162066.1 hypothetical protein -
JMX39_RS26645 15856..16074 + 219 WP_004197642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JMX39_RS26650 16076..16381 + 306 WP_016946795.1 type II toxin-antitoxin system toxin CcdB Toxin
JMX39_RS26655 16539..16922 + 384 WP_063945279.1 hypothetical protein -
JMX39_RS26660 17226..18002 + 777 WP_049245386.1 site-specific integrase -
JMX39_RS26665 18060..18317 - 258 WP_000764642.1 hypothetical protein -
JMX39_RS26670 18446..18550 - 105 WP_032409716.1 hypothetical protein -
JMX39_RS26675 19085..19951 + 867 WP_004118283.1 replication initiation protein -
JMX39_RS26680 20236..20505 - 270 WP_000339857.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..56100 56100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11548.22 Da        Isoelectric Point: 5.6831

>T290631 WP_016946795.1 NZ_LR890319:16076-16381 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSCELYPVVHIGDDSYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8376.34 Da        Isoelectric Point: 4.7405

>AT290631 WP_004197642.1 NZ_LR890319:15856-16074 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References