Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 122188..122840 Replicon plasmid 2
Accession NZ_LR890318
Organism Klebsiella pneumoniae isolate INF215-sc-2280087

Toxin (Protein)


Gene name vagD Uniprot ID A0A8A2Q2K1
Locus tag JMX39_RS26080 Protein ID WP_017901321.1
Coordinates 122188..122613 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag JMX39_RS26085 Protein ID WP_001261275.1
Coordinates 122610..122840 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX39_RS26050 117897..118013 + 117 Protein_125 transposase -
JMX39_RS26055 118138..118308 - 171 Protein_126 LysR family transcriptional regulator -
JMX39_RS26060 118433..118546 + 114 WP_077252861.1 IS3 family transposase -
JMX39_RS26065 118638..120209 - 1572 WP_049257520.1 sensor domain-containing diguanylate cyclase -
JMX39_RS26070 120607..121167 - 561 Protein_129 transposase -
JMX39_RS26075 121202..122170 - 969 WP_102097429.1 IS5 family transposase -
JMX39_RS26080 122188..122613 - 426 WP_017901321.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX39_RS26085 122610..122840 - 231 WP_001261275.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMX39_RS26090 123093..125669 - 2577 WP_017901322.1 EstP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..226712 226712
- flank IS/Tn - - 121202..122170 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15412.91 Da        Isoelectric Point: 7.1364

>T290630 WP_017901321.1 NZ_LR890318:c122613-122188 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVGFVE

Download         Length: 426 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT290630 WP_001261275.1 NZ_LR890318:c122840-122610 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A2Q2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References