Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 52315..53225 Replicon plasmid 2
Accession NZ_LR890318
Organism Klebsiella pneumoniae isolate INF215-sc-2280087

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag JMX39_RS25715 Protein ID WP_004144067.1
Coordinates 52755..53225 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag JMX39_RS25710 Protein ID WP_023287184.1
Coordinates 52315..52758 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX39_RS25690 47731..48480 + 750 Protein_53 IS5 family transposase -
JMX39_RS25695 48509..49477 + 969 WP_074424072.1 IS5 family transposase -
JMX39_RS25700 49532..51019 + 1488 Protein_55 Mov34/MPN/PAD-1 family protein -
JMX39_RS25705 51066..52214 + 1149 Protein_56 translesion error-prone DNA polymerase V subunit UmuC -
JMX39_RS25710 52315..52758 + 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
JMX39_RS25715 52755..53225 + 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
JMX39_RS25720 53312..54280 + 969 WP_201524667.1 IS5 family transposase -
JMX39_RS25725 54488..55561 + 1074 WP_017901404.1 DUF4297 domain-containing protein -
JMX39_RS25730 55558..57222 + 1665 WP_017901405.1 AAA family ATPase -
JMX39_RS25735 57271..57681 - 411 Protein_62 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..226712 226712
- inside IScluster/Tn - - 45587..67354 21767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T290628 WP_004144067.1 NZ_LR890318:52755-53225 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT290628 WP_023287184.1 NZ_LR890318:52315-52758 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References