Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4646353..4646869 Replicon chromosome
Accession NZ_LR890317
Organism Klebsiella pneumoniae isolate INF215-sc-2280087

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMX39_RS22795 Protein ID WP_002886902.1
Coordinates 4646353..4646637 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMX39_RS22800 Protein ID WP_002886901.1
Coordinates 4646627..4646869 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX39_RS22770 4641769..4642077 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMX39_RS22775 4642162..4642335 + 174 WP_032410138.1 hypothetical protein -
JMX39_RS22780 4642338..4643081 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
JMX39_RS22785 4643438..4645576 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMX39_RS22790 4645885..4646349 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX39_RS22795 4646353..4646637 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX39_RS22800 4646627..4646869 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX39_RS22805 4646947..4648857 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JMX39_RS22810 4648880..4650034 - 1155 WP_023302389.1 lactonase family protein -
JMX39_RS22815 4650101..4650841 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T290625 WP_002886902.1 NZ_LR890317:c4646637-4646353 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290625 WP_002886901.1 NZ_LR890317:c4646869-4646627 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References