Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 354939..355585 Replicon chromosome
Accession NZ_LR890317
Organism Klebsiella pneumoniae isolate INF215-sc-2280087

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag JMX39_RS01645 Protein ID WP_004188313.1
Coordinates 354939..355286 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMX39_RS01650 Protein ID WP_040152325.1
Coordinates 355286..355585 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX39_RS01635 350865..352298 + 1434 WP_002920564.1 glycogen synthase GlgA -
JMX39_RS01640 352316..354763 + 2448 WP_002920561.1 glycogen phosphorylase -
JMX39_RS01645 354939..355286 + 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX39_RS01650 355286..355585 + 300 WP_040152325.1 helix-turn-helix domain-containing protein Antitoxin
JMX39_RS01655 355648..357156 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
JMX39_RS01660 357361..357690 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JMX39_RS01665 357741..358571 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
JMX39_RS01670 358621..359379 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T290614 WP_004188313.1 NZ_LR890317:354939-355286 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10830.61 Da        Isoelectric Point: 10.1464

>AT290614 WP_040152325.1 NZ_LR890317:355286-355585 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure

References