Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2597768..2599356 Replicon chromosome
Accession NZ_LR890307
Organism Klebsiella pneumoniae isolate INF188-sc-2280054

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag JMW12_RS12795 Protein ID WP_023301940.1
Coordinates 2597768..2599090 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW12_RS12800 Protein ID WP_024622638.1
Coordinates 2599090..2599356 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW12_RS12780 2592824..2595325 + 2502 WP_023301938.1 fimbrial biogenesis outer membrane usher protein -
JMW12_RS12785 2595313..2596317 + 1005 WP_023301939.1 type 1 fimbrial protein -
JMW12_RS12790 2596459..2597751 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW12_RS12795 2597768..2599090 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW12_RS12800 2599090..2599356 - 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW12_RS12805 2599621..2599947 - 327 WP_004184023.1 hydroxyisourate hydrolase -
JMW12_RS12810 2599944..2600444 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW12_RS12815 2600422..2601801 - 1380 WP_023301941.1 purine permease -
JMW12_RS12820 2602147..2603301 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW12_RS12825 2603282..2604205 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T290595 WP_023301940.1 NZ_LR890307:c2599090-2597768 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT290595 WP_024622638.1 NZ_LR890307:c2599356-2599090 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure

References