Detailed information of TA system TA290556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2132064..2133753
• Replicon: chromosome
• Accession: NZ_LR890299
• Organism: Escherichia coli isolate MSB1_3B-sc-2280406

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: JM188_RS10320
• Protein ID: WP_000365809.1
• Coordinates: 2132064..2132984 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JM188_RS10325
• Protein ID: WP_001550661.1
• Coordinates: 2132971..2133753 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JM188_RS10305	2128154..2129281	-	1128	WP_001550663.1	MFS transporter	-
JM188_RS10310	2129423..2130481	-	1059	WP_122987197.1	alpha/beta hydrolase	-
JM188_RS10315	2130746..2131630	+	885	WP_001119037.1	LysR family transcriptional regulator	-
JM188_RS10320	2132064..2132984	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JM188_RS10325	2132971..2133753	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JM188_RS10330	2134069..2137278	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
JM188_RS10335	2137439..2137579	+	141	WP_001308408.1	ash family protein	-
JM188_RS10340	2137625..2138095	+	471	WP_000201185.1	hypothetical protein	-
JM188_RS10345	2138092..2138194	+	103	Protein_2027	helix-turn-helix domain-containing protein	-
JM188_RS10350	2138286..2138444	+	159	Protein_2028	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T290556 WP_000365809.1 NZ_LR890299:c2132984-2132064 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT290556 WP_001550661.1 NZ_LR890299:c2133753-2132971 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: V0Z9M0