Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2610632..2612220 Replicon chromosome
Accession NZ_LR890291
Organism Klebsiella pneumoniae strain KSB1_1B

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMW65_RS12825 Protein ID WP_049109073.1
Coordinates 2610632..2611954 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW65_RS12830 Protein ID WP_002904790.1
Coordinates 2611954..2612220 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW65_RS12810 2605688..2608189 + 2502 WP_094645008.1 fimbrial biogenesis outer membrane usher protein -
JMW65_RS12815 2608177..2609181 + 1005 WP_016946380.1 type 1 fimbrial protein -
JMW65_RS12820 2609323..2610615 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW65_RS12825 2610632..2611954 - 1323 WP_049109073.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW65_RS12830 2611954..2612220 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW65_RS12835 2612485..2612811 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW65_RS12840 2612808..2613308 - 501 WP_094645009.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW65_RS12845 2613286..2614665 - 1380 WP_004184021.1 purine permease -
JMW65_RS12850 2615011..2616165 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW65_RS12855 2616146..2617069 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2401412..2647702 246290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49115.40 Da        Isoelectric Point: 7.5357

>T290537 WP_049109073.1 NZ_LR890291:c2611954-2610632 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPAGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290537 WP_002904790.1 NZ_LR890291:c2612220-2611954 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References