Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5078979..5079604 Replicon chromosome
Accession NZ_LR890286
Organism Klebsiella pneumoniae isolate INF156-sc-2280002

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JMV92_RS24705 Protein ID WP_002882817.1
Coordinates 5078979..5079362 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMV92_RS24710 Protein ID WP_004150355.1
Coordinates 5079362..5079604 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV92_RS24690 5076345..5077247 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMV92_RS24695 5077244..5077879 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMV92_RS24700 5077876..5078805 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMV92_RS24705 5078979..5079362 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JMV92_RS24710 5079362..5079604 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMV92_RS24715 5079809..5080726 + 918 WP_065803683.1 alpha/beta hydrolase -
JMV92_RS24720 5080740..5081681 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMV92_RS24725 5081726..5082163 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMV92_RS24730 5082160..5083020 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMV92_RS24735 5083014..5083613 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T290491 WP_002882817.1 NZ_LR890286:c5079362-5078979 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT290491 WP_004150355.1 NZ_LR890286:c5079604-5079362 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References