Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2532832..2534420 Replicon chromosome
Accession NZ_LR890286
Organism Klebsiella pneumoniae isolate INF156-sc-2280002

Toxin (Protein)


Gene name hipA Uniprot ID A0A486RAG1
Locus tag JMV92_RS12395 Protein ID WP_016946382.1
Coordinates 2532832..2534154 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMV92_RS12400 Protein ID WP_002904790.1
Coordinates 2534154..2534420 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV92_RS12380 2527888..2530389 + 2502 WP_023282574.1 fimbrial biogenesis outer membrane usher protein -
JMV92_RS12385 2530377..2531381 + 1005 WP_016946380.1 type 1 fimbrial protein -
JMV92_RS12390 2531523..2532815 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
JMV92_RS12395 2532832..2534154 - 1323 WP_016946382.1 type II toxin-antitoxin system HipA family toxin Toxin
JMV92_RS12400 2534154..2534420 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMV92_RS12405 2534686..2535012 - 327 WP_004215084.1 hydroxyisourate hydrolase -
JMV92_RS12410 2535009..2535509 - 501 WP_023282573.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMV92_RS12415 2535487..2536866 - 1380 WP_004184021.1 purine permease -
JMV92_RS12420 2537212..2538366 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMV92_RS12425 2538347..2539270 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5358

>T290486 WP_016946382.1 NZ_LR890286:c2534154-2532832 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290486 WP_002904790.1 NZ_LR890286:c2534420-2534154 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RAG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References