Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2372868..2373557 Replicon chromosome
Accession NZ_LR890240
Organism Klebsiella pneumoniae isolate INF329-sc-2280137

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag JMV78_RS11580 Protein ID WP_021469727.1
Coordinates 2372868..2373185 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMV78_RS11585 Protein ID WP_040147778.1
Coordinates 2373261..2373557 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV78_RS11550 2368570..2369079 + 510 WP_002906702.1 GNAT family N-acetyltransferase -
JMV78_RS11555 2369089..2370015 + 927 WP_032416224.1 amino acid ABC transporter permease -
JMV78_RS11560 2369999..2370778 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
JMV78_RS11565 2370817..2371668 + 852 WP_014343117.1 transporter substrate-binding domain-containing protein -
JMV78_RS11570 2371746..2372363 + 618 WP_040147782.1 glutathione S-transferase family protein -
JMV78_RS11575 2372434..2372661 + 228 WP_002906690.1 tautomerase PptA -
JMV78_RS11580 2372868..2373185 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV78_RS11585 2373261..2373557 + 297 WP_040147778.1 helix-turn-helix domain-containing protein Antitoxin
JMV78_RS11590 2373636..2374082 + 447 WP_004175959.1 hypothetical protein -
JMV78_RS11595 2374123..2375739 - 1617 WP_040147777.1 carbohydrate porin -
JMV78_RS11600 2375783..2377165 - 1383 WP_099743292.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T290379 WP_021469727.1 NZ_LR890240:2372868-2373185 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11032.88 Da        Isoelectric Point: 6.4721

>AT290379 WP_040147778.1 NZ_LR890240:2373261-2373557 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMPMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRQPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure

References