Detailed information of TA system TA290160

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4380226..4381024
• Replicon: chromosome
• Accession: NZ_LR883050
• Organism: Escherichia coli isolate L1_E925

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: JL017_RS21385
• Protein ID: WP_001394823.1
• Coordinates: 4380647..4381024 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JL017_RS21380
• Protein ID: WP_024169686.1
• Coordinates: 4380226..4380600 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL017_RS21340	4376179..4376352	-	174	Protein_4174	transposase	-
JL017_RS21345	4376351..4376470	+	120	Protein_4175	AAA family ATPase	-
JL017_RS21350	4376520..4377608	-	1089	Protein_4176	ISL3 family transposase	-
JL017_RS21355	4377740..4377850	+	111	Protein_4177	DUF905 family protein	-
JL017_RS21360	4377951..4378769	+	819	WP_001397454.1	DUF945 domain-containing protein	-
JL017_RS21365	4378861..4379346	+	486	WP_001397456.1	antirestriction protein	-
JL017_RS21370	4379362..4379838	+	477	WP_001186709.1	RadC family protein	-
JL017_RS21375	4379925..4380146	+	222	WP_000691818.1	DUF987 domain-containing protein	-
JL017_RS21380	4380226..4380600	+	375	WP_024169686.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JL017_RS21385	4380647..4381024	+	378	WP_001394823.1	TA system toxin CbtA family protein	Toxin
JL017_RS21390	4381021..4381509	+	489	WP_001394824.1	hypothetical protein	-
JL017_RS21395	4381521..4381718	+	198	WP_001394825.1	DUF957 domain-containing protein	-
JL017_RS21400	4381803..4382645	+	843	WP_001394826.1	DUF4942 domain-containing protein	-
JL017_RS21405	4383456..4384994	+	1539	WP_001187173.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4351010..4392811	41801
	-	flank	IS/Tn	-	-	4376712..4377596	884

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14206.19 Da
• Isoelectric Point: 8.2905

>T290160 WP_001394823.1 NZ_LR883050:4380647-4381024 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13862.66 Da
• Isoelectric Point: 6.3139

>AT290160 WP_024169686.1 NZ_LR883050:4380226-4380600 [Escherichia coli]
VSDTLHKTNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFLLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Nucleotide

• Length: 375 bp