Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2811561..2812213 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JOA04_RS12980 Protein ID WP_003412752.1
Coordinates 2811788..2812213 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag JOA04_RS12975 Protein ID WP_003412749.1
Coordinates 2811561..2811782 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS12960 2809801..2810007 - 207 WP_003899347.1 hypothetical protein -
JOA04_RS12965 2810143..2810766 + 624 WP_202582046.1 TIGR00725 family protein -
JOA04_RS12970 2810756..2811508 + 753 WP_105799954.1 hypothetical protein -
JOA04_RS12975 2811561..2811782 + 222 WP_003412749.1 antitoxin Antitoxin
JOA04_RS12980 2811788..2812213 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JOA04_RS12985 2812236..2813417 - 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
JOA04_RS12990 2813414..2814460 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JOA04_RS12995 2814471..2815574 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JOA04_RS13000 2815833..2816654 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
JOA04_RS13005 2816651..2817208 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T289941 WP_003412752.1 NZ_LR882500:2811788-2812213 [Mycobacterium tuberculosis variant microti]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT289941 WP_003412749.1 NZ_LR882500:2811561-2811782 [Mycobacterium tuberculosis variant microti]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References