Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1695320..1695936 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag JOA04_RS07860 Protein ID WP_003407593.1
Coordinates 1695619..1695936 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag JOA04_RS07855 Protein ID WP_003900349.1
Coordinates 1695320..1695622 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS07845 1691206..1693053 + 1848 WP_202582012.1 methylmalonyl-CoA mutase small subunit -
JOA04_RS07850 1693054..1695306 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
JOA04_RS07855 1695320..1695622 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
JOA04_RS07860 1695619..1695936 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
JOA04_RS07865 1695933..1696937 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
JOA04_RS07870 1696990..1698279 + 1290 WP_003407599.1 serine hydrolase -
JOA04_RS07875 1698352..1699125 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
JOA04_RS07880 1699183..1699374 - 192 WP_003407609.1 dodecin family protein -
JOA04_RS07885 1699405..1699629 - 225 WP_160522526.1 NUDIX domain-containing protein -
JOA04_RS07890 1699899..1700927 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T289926 WP_003407593.1 NZ_LR882500:1695619-1695936 [Mycobacterium tuberculosis variant microti]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT289926 WP_003900349.1 NZ_LR882500:1695320-1695622 [Mycobacterium tuberculosis variant microti]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References