Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2846310..2846950 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag JN993_RS13120 Protein ID WP_003412970.1
Coordinates 2846310..2846729 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag JN993_RS13125 Protein ID WP_003412975.1
Coordinates 2846726..2846950 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS13090 2841895..2842617 - 723 WP_003412957.1 DUF1906 domain-containing protein -
JN993_RS13095 2843134..2843361 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
JN993_RS13100 2843358..2843759 + 402 WP_003412963.1 PIN domain-containing protein -
JN993_RS13105 2843794..2844714 - 921 WP_003412965.1 restriction endonuclease -
JN993_RS13110 2845055..2845300 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JN993_RS13115 2845359..2846309 + 951 WP_003911916.1 Lsr2 family protein -
JN993_RS13120 2846310..2846729 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
JN993_RS13125 2846726..2846950 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
JN993_RS13130 2846981..2849825 - 2845 Protein_2591 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
JN993_RS13135 2849897..2850298 - 402 WP_003412981.1 hypothetical protein -
JN993_RS13140 2850298..2850768 - 471 WP_003412985.1 transcription antitermination factor NusB -
JN993_RS13145 2850771..2851334 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T289702 WP_003412970.1 NZ_LR882496:c2846729-2846310 [Mycobacterium tuberculosis variant microti]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT289702 WP_003412975.1 NZ_LR882496:c2846950-2846726 [Mycobacterium tuberculosis variant microti]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References