Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2362067..2362762 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN993_RS10860 Protein ID WP_105799725.1
Coordinates 2362067..2362501 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN993_RS10865 Protein ID WP_003410814.1
Coordinates 2362508..2362762 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS10850 2358221..2361262 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
JN993_RS10855 2361255..2362088 + 834 WP_003899172.1 SWIM zinc finger family protein -
JN993_RS10860 2362067..2362501 - 435 WP_105799725.1 type II toxin-antitoxin system VapC family toxin Toxin
JN993_RS10865 2362508..2362762 - 255 WP_003410814.1 antitoxin Antitoxin
JN993_RS10870 2362778..2363035 - 258 WP_003410816.1 hypothetical protein -
JN993_RS10875 2363983..2364279 + 297 WP_003410820.1 PE family protein -
JN993_RS10880 2364335..2365066 + 732 WP_003900467.1 PPE family protein -
JN993_RS10885 2365606..2366352 - 747 WP_003901330.1 proteasome subunit alpha -
JN993_RS10890 2366349..2367224 - 876 WP_003411023.1 proteasome subunit beta -
JN993_RS10895 2367221..2367415 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15648.05 Da        Isoelectric Point: 7.4681

>T289699 WP_105799725.1 NZ_LR882496:c2362501-2362067 [Mycobacterium tuberculosis variant microti]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADIVARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT289699 WP_003410814.1 NZ_LR882496:c2362762-2362508 [Mycobacterium tuberculosis variant microti]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References