Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2250368..2250994 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag JN993_RS10385 Protein ID WP_003410075.1
Coordinates 2250596..2250994 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN993_RS10380 Protein ID WP_019283586.1
Coordinates 2250368..2250595 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS10370 2248407..2248751 - 345 WP_003410065.1 ferredoxin family protein -
JN993_RS10375 2248940..2250109 - 1170 WP_003899126.1 ATP-binding protein -
JN993_RS10380 2250368..2250595 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN993_RS10385 2250596..2250994 + 399 WP_003410075.1 PIN domain nuclease Toxin
JN993_RS10390 2251177..2251608 - 432 WP_105799633.1 MarR family winged helix-turn-helix transcriptional regulator -
JN993_RS10395 2251709..2252143 + 435 WP_003914358.1 DUF1398 domain-containing protein -
JN993_RS10400 2252580..2252759 - 180 Protein_2055 hypothetical protein -
JN993_RS10405 2252820..2253467 + 648 WP_071854215.1 transposase -
JN993_RS10410 2253421..2254011 + 591 WP_003899131.1 IS110 family transposase -
JN993_RS10415 2254139..2255395 - 1257 WP_003410095.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T289696 WP_003410075.1 NZ_LR882496:2250596-2250994 [Mycobacterium tuberculosis variant microti]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT289696 WP_019283586.1 NZ_LR882496:2250368-2250595 [Mycobacterium tuberculosis variant microti]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References