Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 264313..264944 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag IHP09_RS01175 Protein ID WP_001259385.1
Coordinates 264313..264588 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag IHP09_RS01180 Protein ID WP_000593554.1
Coordinates 264585..264944 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS01160 259317..260384 + 1068 WP_000361467.1 HlyD family secretion protein -
IHP09_RS01165 260381..263116 + 2736 WP_191536189.1 ribosome-associated ATPase/putative transporter RbbA -
IHP09_RS01170 263116..264240 + 1125 WP_001314210.1 ABC transporter permease -
IHP09_RS01175 264313..264588 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
IHP09_RS01180 264585..264944 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IHP09_RS01185 264994..265854 - 861 WP_001131782.1 class II aldolase -
IHP09_RS01190 265886..266155 - 270 WP_000933060.1 HPr family phosphocarrier protein -
IHP09_RS01195 266145..267653 - 1509 WP_001298718.1 carbohydrate kinase -
IHP09_RS01200 267646..269004 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
IHP09_RS01205 269081..269362 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
IHP09_RS01210 269359..269832 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 256696..271203 14507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T289603 WP_001259385.1 NZ_LR882057:264313-264588 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT289603 WP_000593554.1 NZ_LR882057:264585-264944 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References