Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3715984..3716783 Replicon chromosome
Accession NZ_LR882050
Organism Escherichia coli isolate 2016-02-324

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag IHP20_RS17895 Protein ID WP_000347251.1
Coordinates 3715984..3716448 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IHP20_RS17900 Protein ID WP_001307405.1
Coordinates 3716448..3716783 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP20_RS17865 3710985..3711419 - 435 WP_191528394.1 PTS sugar transporter subunit IIA -
IHP20_RS17870 3711437..3712315 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IHP20_RS17875 3712305..3713084 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IHP20_RS17880 3713095..3713568 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
IHP20_RS17885 3713591..3714871 - 1281 WP_000681905.1 tagatose-bisphosphate aldolase subunit KbaZ -
IHP20_RS17890 3715120..3715929 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IHP20_RS17895 3715984..3716448 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IHP20_RS17900 3716448..3716783 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IHP20_RS17905 3716932..3718503 - 1572 WP_001273753.1 galactarate dehydratase -
IHP20_RS17910 3718878..3720212 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
IHP20_RS17915 3720228..3720998 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T289573 WP_000347251.1 NZ_LR882050:c3716448-3715984 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT289573 WP_001307405.1 NZ_LR882050:c3716783-3716448 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References