Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 810064..810702 Replicon chromosome
Accession NZ_LR882050
Organism Escherichia coli isolate 2016-02-324

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag IHP20_RS03995 Protein ID WP_000813794.1
Coordinates 810526..810702 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IHP20_RS03990 Protein ID WP_001270286.1
Coordinates 810064..810480 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP20_RS03970 805216..806157 - 942 WP_001251313.1 ABC transporter permease -
IHP20_RS03975 806158..807171 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
IHP20_RS03980 807189..808334 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
IHP20_RS03985 808579..809985 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
IHP20_RS03990 810064..810480 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
IHP20_RS03995 810526..810702 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
IHP20_RS04000 810924..811154 + 231 WP_000494244.1 YncJ family protein -
IHP20_RS04005 811246..813207 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
IHP20_RS04010 813280..813816 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
IHP20_RS04015 813908..815083 + 1176 Protein_791 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T289567 WP_000813794.1 NZ_LR882050:c810702-810526 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT289567 WP_001270286.1 NZ_LR882050:c810480-810064 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References