Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 637787..638313 Replicon chromosome
Accession NZ_LR882050
Organism Escherichia coli isolate 2016-02-324

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IHP20_RS03165 Protein ID WP_000323025.1
Coordinates 638026..638313 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IHP20_RS03160 Protein ID WP_000534858.1
Coordinates 637787..638026 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP20_RS03135 633149..633505 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
IHP20_RS03140 634116..634403 + 288 Protein_616 hypothetical protein -
IHP20_RS03145 635172..636485 + 1314 WP_000589005.1 ISNCY family transposase -
IHP20_RS03150 636922..637254 - 333 WP_001301033.1 protein FlxA -
IHP20_RS03155 637457..637762 - 306 WP_001326990.1 hypothetical protein -
IHP20_RS03160 637787..638026 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IHP20_RS03165 638026..638313 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IHP20_RS03170 638385..638540 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IHP20_RS03175 638757..639008 + 252 WP_000980994.1 hypothetical protein -
IHP20_RS03180 639075..639353 + 279 WP_012304870.1 hypothetical protein -
IHP20_RS03185 639355..640404 + 1050 WP_001265198.1 DUF968 domain-containing protein -
IHP20_RS03190 640418..641170 + 753 WP_001047135.1 antitermination protein -
IHP20_RS03195 641448..641537 - 90 WP_120795389.1 hypothetical protein -
IHP20_RS03200 641592..641804 - 213 WP_000087756.1 cold shock-like protein CspF -
IHP20_RS03205 642105..642320 + 216 WP_000066484.1 cold shock-like protein CspB -
IHP20_RS03210 643074..643289 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 612913..673796 60883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289565 WP_000323025.1 NZ_LR882050:638026-638313 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289565 WP_000534858.1 NZ_LR882050:637787-638026 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References