Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1756748..1757250 Replicon chromosome
Accession NZ_LR881940
Organism Escherichia coli isolate 2015-01-2097

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag IHP11_RS08270 Protein ID WP_000767831.1
Coordinates 1756996..1757250 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IHP11_RS08265 Protein ID WP_001259255.1
Coordinates 1756748..1756999 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP11_RS08240 1751925..1752992 - 1068 WP_191521758.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
IHP11_RS08245 1752992..1754062 - 1071 WP_039000891.1 histidinol-phosphate transaminase -
IHP11_RS08250 1754059..1755363 - 1305 WP_001446927.1 histidinol dehydrogenase -
IHP11_RS08255 1755369..1756268 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
IHP11_RS08260 1756414..1756464 - 51 WP_001364200.1 his operon leader peptide -
IHP11_RS08265 1756748..1756999 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IHP11_RS08270 1756996..1757250 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IHP11_RS08275 1757333..1758157 + 825 WP_000754737.1 SDR family oxidoreductase -
IHP11_RS08280 1758203..1759132 + 930 WP_000803366.1 LysR family transcriptional regulator -
IHP11_RS08285 1759347..1759409 + 63 WP_010723108.1 membrane protein YoeI -
IHP11_RS08290 1759399..1760757 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IHP11_RS08295 1760936..1761994 + 1059 WP_000492321.1 transport protein YeeE -
IHP11_RS08300 1762008..1762235 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T289541 WP_000767831.1 NZ_LR881940:1756996-1757250 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289541 WP_001259255.1 NZ_LR881940:1756748-1756999 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References