Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 50515..51176 Replicon chromosome
Accession NZ_LR881936
Organism Enterobacter cancerogenus strain UPC1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ENTER_RS00260 Protein ID WP_202561431.1
Coordinates 50778..51176 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ENTER_RS00255 Protein ID WP_202561430.1
Coordinates 50515..50775 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTER_RS00225 45623..45937 - 315 WP_042321291.1 PTS sugar transporter subunit IIB -
ENTER_RS00230 46229..47179 + 951 WP_006177643.1 LacI family transcriptional regulator -
ENTER_RS00235 47274..47570 - 297 WP_006177644.1 hypothetical protein -
ENTER_RS00240 47753..48172 + 420 WP_006177646.1 GNAT family N-acetyltransferase -
ENTER_RS00245 48169..48816 - 648 WP_006177647.1 TetR/AcrR family transcriptional regulator -
ENTER_RS00250 48910..50403 + 1494 WP_202561429.1 MFS transporter -
ENTER_RS00255 50515..50775 + 261 WP_202561430.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ENTER_RS00260 50778..51176 + 399 WP_202561431.1 type II toxin-antitoxin system VapC family toxin Toxin
ENTER_RS00265 51311..52111 + 801 WP_202561432.1 lipoprotein NlpA -
ENTER_RS00270 52117..52797 - 681 WP_202561433.1 EAL domain-containing protein -
ENTER_RS00275 52874..53494 - 621 WP_102891870.1 response regulator transcription factor -
ENTER_RS00280 54067..54702 + 636 WP_042321474.1 response regulator transcription factor -
ENTER_RS00285 54743..55807 - 1065 WP_006177656.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14688.81 Da        Isoelectric Point: 5.5081

>T289487 WP_202561431.1 NZ_LR881936:50778-51176 [Enterobacter cancerogenus]
MRHMLDTNMVSHLVRQHPEVVSQYSKIAPDDMCISSVTEAELLYGVAKKHSPKLKETILEFLKTITVCDWDSEAATTYGA
LRAAMEKRGNVMGDLDQLIAAHAISQGTTIVTNDRAFLMVQELSVEDWTHAA

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9981.34 Da        Isoelectric Point: 8.5752

>AT289487 WP_202561430.1 NZ_LR881936:50515-50775 [Enterobacter cancerogenus]
MEHKAKLFKRGRSQAVMLPAEFTFDAESVYIRRDDDGNVVLTAISEKARHREIFLRLLKQTPVPDSFLSKEERNQSYTSR
DPLEGL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References