Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2466279..2467867 Replicon chromosome
Accession NZ_LR792628
Organism Klebsiella pneumoniae isolate SB5881

Toxin (Protein)


Gene name hipA Uniprot ID W9B834
Locus tag HU711_RS12020 Protein ID WP_016529318.1
Coordinates 2466545..2467867 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HU711_RS12015 Protein ID WP_004176198.1
Coordinates 2466279..2466545 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU711_RS11990 2461402..2462325 + 924 WP_016529218.1 LysR family hpxDE operon transcriptional regulator HpxR -
HU711_RS11995 2462306..2463460 - 1155 WP_046043281.1 FAD-dependent urate hydroxylase HpxO -
HU711_RS12000 2463806..2465185 + 1380 WP_004176204.1 purine permease -
HU711_RS12005 2465163..2465663 + 501 WP_046043283.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HU711_RS12010 2465660..2465986 + 327 WP_002904788.1 hydroxyisourate hydrolase -
HU711_RS12015 2466279..2466545 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HU711_RS12020 2466545..2467867 + 1323 WP_016529318.1 type II toxin-antitoxin system HipA family toxin Toxin
HU711_RS12025 2467884..2469176 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HU711_RS12030 2469318..2470322 - 1005 WP_009308876.1 type 1 fimbrial protein -
HU711_RS12035 2470310..2472811 - 2502 WP_174893385.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iroE / mgtC 2431408..2647336 215928


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5366

>T289353 WP_016529318.1 NZ_LR792628:2466545-2467867 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT289353 WP_004176198.1 NZ_LR792628:2466279-2466545 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B834

Antitoxin

Source ID Structure

References