Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2864164..2864878 Replicon chromosome
Accession NC_020245
Organism Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag K60_RS13395 Protein ID WP_003413460.1
Coordinates 2864438..2864878 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag K60_RS13390 Protein ID WP_003413456.1
Coordinates 2864164..2864451 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K60_RS13355 2859596..2859841 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
K60_RS13360 2859838..2860242 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
K60_RS13365 2860459..2861079 + 621 WP_003413441.1 DUF4178 domain-containing protein -
K60_RS13370 2861090..2861584 + 495 WP_003413444.1 DUF2617 family protein -
K60_RS13375 2861581..2862012 + 432 WP_003413445.1 DUF4247 domain-containing protein -
K60_RS13380 2862037..2862485 + 449 Protein_2603 DUF350 domain-containing protein -
K60_RS13385 2862482..2864053 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
K60_RS13390 2864164..2864451 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
K60_RS13395 2864438..2864878 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
K60_RS13400 2864899..2865654 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
K60_RS13405 2865787..2866383 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
K60_RS13410 2866391..2867236 - 846 WP_010950749.1 acyl-CoA thioesterase II -
K60_RS13415 2867265..2868164 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
K60_RS13420 2868292..2868966 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T28909 WP_003413460.1 NC_020245:2864438-2864878 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T28909 NC_020245:2864438-2864878 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT28909 WP_003413456.1 NC_020245:2864164-2864451 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT28909 NC_020245:2864164-2864451 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References