288988

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 199451..199986 Replicon plasmid paAPEC5202
Accession NZ_LR740759
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name relE Uniprot ID V0VJJ7
Locus tag APEC5202_RS25900 Protein ID WP_000222760.1
Coordinates 199699..199986 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag APEC5202_RS25895 Protein ID WP_001132900.1
Coordinates 199451..199702 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS25860 194577..195137 + 561 WP_000139315.1 fertility inhibition protein FinO -
APEC5202_RS25865 195273..195485 + 213 WP_001299730.1 ANR family transcriptional regulator -
APEC5202_RS26820 195731..195805 + 75 Protein_196 endonuclease -
- 196061..196122 - 62 NuclAT_1 - -
- 196061..196122 - 62 NuclAT_1 - -
- 196061..196122 - 62 NuclAT_1 - -
- 196061..196122 - 62 NuclAT_1 - -
APEC5202_RS25870 196109..196315 + 207 WP_001351576.1 type I toxin-antitoxin system Hok family toxin -
APEC5202_RS25875 196599..196856 + 258 WP_000083845.1 replication regulatory protein RepA -
APEC5202_RS25880 197088..197162 + 75 WP_001442103.1 RepA leader peptide Tap -
APEC5202_RS25885 197155..197637 + 483 WP_001273588.1 hypothetical protein -
APEC5202_RS25890 197630..198487 + 858 WP_103529982.1 incFII family plasmid replication initiator RepA -
APEC5202_RS25895 199451..199702 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
APEC5202_RS25900 199699..199986 + 288 WP_000222760.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APEC5202_RS25905 200426..200773 - 348 Protein_204 IS1-like element IS1A family transposase -
APEC5202_RS25910 200862..201884 + 1023 WP_000255956.1 IS21-like element IS100 family transposase -
APEC5202_RS25915 201884..202663 + 780 WP_001513481.1 IS21-like element IS100kyp family helper ATPase IstB -
APEC5202_RS25920 202718..203082 - 365 Protein_207 IS1 family transposase -
APEC5202_RS25925 203182..204403 + 1222 Protein_208 ISL3 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(B) / sitABCD vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..223939 223939


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-83)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11105.15 Da        Isoelectric Point: 10.5832

>T288988 WP_000222760.1 NZ_LR740759:199699-199986 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT288988 WP_001132900.1 NZ_LR740759:199451-199702 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0VJJ7


Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References