Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1865679..1866304 Replicon chromosome
Accession NZ_LR699010
Organism Lachnoanaerobaculum umeaense isolate MGYG-HGUT-02522

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FX093_RS08430 Protein ID WP_111525495.1
Coordinates 1865679..1866080 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FX093_RS08435 Protein ID WP_111525494.1
Coordinates 1866077..1866304 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX093_RS08410 1863363..1863668 - 306 WP_111525499.1 ribosomal L7Ae/L30e/S12e/Gadd45 family protein -
FX093_RS08415 1863655..1863939 - 285 WP_111525498.1 YlxR family protein -
FX093_RS08420 1863917..1865077 - 1161 WP_111525497.1 transcription termination/antitermination protein NusA -
FX093_RS08425 1865096..1865596 - 501 WP_111525496.1 ribosome maturation factor RimP -
FX093_RS08430 1865679..1866080 - 402 WP_111525495.1 type II toxin-antitoxin system VapC family toxin Toxin
FX093_RS08435 1866077..1866304 - 228 WP_111525494.1 antitoxin Antitoxin
FX093_RS08440 1866426..1868177 - 1752 WP_111525493.1 DUF5050 domain-containing protein -
FX093_RS08445 1868196..1869986 - 1791 WP_162902565.1 YARHG domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(9-51)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15124.54 Da        Isoelectric Point: 7.8637

>T288774 WP_111525495.1 NZ_LR699010:c1866080-1865679 [Lachnoanaerobaculum umeaense]
MRYMLDTNICIYIIKNNPDSVIEELKRHDPKEICISSITYAELIHGVEKSKAVGKNRLALTLFLSNIEVLDFDTNAANNY
GKIRAYLEKKGTLIGQLDMMIAAHAQSLGYSIVTNNIKEFTRVPDLTVYNWVK

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8785.10 Da        Isoelectric Point: 4.4432

>AT288774 WP_111525494.1 NZ_LR699010:c1866304-1866077 [Lachnoanaerobaculum umeaense]
MLAAKIFENGRSQAVRLPKEYRFDCDEVMANKIGDVLILLPKNSKWDSFITAIDMFSDDFMIDREDNLVQKREEL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References