Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1332787..1333353 Replicon chromosome
Accession NZ_LR699003
Organism Bifidobacterium breve isolate MGYG-HGUT-02469

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag FX083_RS05980 Protein ID WP_014483710.1
Coordinates 1333060..1333353 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag FX083_RS05975 Protein ID WP_014483711.1
Coordinates 1332787..1333056 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX083_RS05950 1328537..1329232 - 696 WP_015438830.1 response regulator transcription factor -
FX083_RS05955 1329358..1329873 + 516 WP_013140733.1 hypothetical protein -
FX083_RS05960 1329870..1330760 + 891 WP_015438831.1 hypothetical protein -
FX083_RS05965 1330757..1331437 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
FX083_RS05970 1331434..1332602 + 1169 Protein_1107 ABC transporter permease -
FX083_RS05975 1332787..1333056 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FX083_RS05980 1333060..1333353 + 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
FX083_RS05990 1334022..1334573 + 552 WP_015438834.1 RNA polymerase sigma factor -
FX083_RS05995 1334607..1335434 + 828 WP_015438835.1 hypothetical protein -
FX083_RS06000 1335566..1336192 + 627 WP_015438836.1 hypothetical protein -
FX083_RS06005 1336189..1336971 + 783 WP_015438837.1 hypothetical protein -
FX083_RS06010 1337023..1337898 + 876 WP_015438838.1 ABC transporter ATP-binding protein -
FX083_RS06015 1337952..1338350 + 399 WP_015438839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1326693..1352222 25529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T288723 WP_014483710.1 NZ_LR699003:1333060-1333353 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT288723 WP_014483711.1 NZ_LR699003:1332787-1333056 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References