Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1259912..1260581 Replicon chromosome
Accession NZ_LR590465
Organism Haemophilus influenzae strain NCTC8468

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag FGK83_RS06265 Protein ID WP_015701504.1
Coordinates 1259912..1260295 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag FGK83_RS06270 Protein ID WP_005651224.1
Coordinates 1260279..1260581 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK83_RS06230 1256672..1256995 + 324 WP_114877442.1 DUF2190 family protein -
FGK83_RS06235 1256976..1257287 + 312 WP_015701509.1 hypothetical protein -
FGK83_RS06240 1257290..1257820 + 531 WP_015701508.1 phage tail protein -
FGK83_RS06245 1257829..1258239 + 411 WP_112072217.1 phage tail protein -
FGK83_RS06250 1258242..1258892 + 651 WP_112072216.1 hypothetical protein -
FGK83_RS06255 1259167..1259574 + 408 WP_059358263.1 hypothetical protein -
FGK83_RS06260 1259619..1259843 + 225 WP_038440708.1 DUF4035 domain-containing protein -
FGK83_RS06265 1259912..1260295 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGK83_RS06270 1260279..1260581 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
FGK83_RS06275 1260597..1260833 + 237 WP_101494098.1 hypothetical protein -
FGK83_RS06280 1260885..1264277 + 3393 WP_138171923.1 tape measure protein -
FGK83_RS06285 1264274..1264600 + 327 WP_112072214.1 phage tail protein -
FGK83_RS06290 1264600..1265313 + 714 WP_138171924.1 phage minor tail protein L -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1226936..1272929 45993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T288466 WP_015701504.1 NZ_LR590465:1259912-1260295 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT288466 WP_005651224.1 NZ_LR590465:1260279-1260581 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References