288130

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 31531..32050 Replicon plasmid 4
Accession NZ_LR135310
Organism Enterococcus faecium isolate E7240

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag EQB75_RS16890 Protein ID WP_000588503.1
Coordinates 31793..32050 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag EQB75_RS16885 Protein ID WP_000388479.1
Coordinates 31531..31800 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB75_RS16845 26900..27577 + 678 WP_047211305.1 replication initiation protein -
EQB75_RS16850 27714..28130 - 417 WP_002305824.1 hypothetical protein -
EQB75_RS16855 28132..28413 - 282 WP_002347613.1 hypothetical protein -
EQB75_RS16860 28696..28782 - 87 WP_106914087.1 type I toxin-antitoxin system Fst family toxin -
EQB75_RS16865 29518..30198 - 681 Protein_34 IS6 family transposase -
EQB75_RS16870 30274..30840 + 567 Protein_35 hypothetical protein -
EQB75_RS16880 31221..31400 + 180 WP_001120991.1 hypothetical protein -
EQB75_RS16885 31531..31800 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB75_RS16890 31793..32050 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
EQB75_RS16895 32688..33512 + 825 WP_001809248.1 hypothetical protein -
EQB75_RS16900 33677..34291 - 615 WP_001261742.1 recombinase family protein -
EQB75_RS16905 34741..36066 + 1326 WP_000969590.1 Y-family DNA polymerase -
EQB75_RS16910 36059..36409 + 351 WP_000568378.1 hypothetical protein -
EQB75_RS16915 36406..36585 + 180 WP_001021554.1 hypothetical protein -
EQB75_RS16920 36721..37011 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..38828 38828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T288130 WP_000588503.1 NZ_LR135310:31793-32050 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT288130 WP_000388479.1 NZ_LR135310:31531-31800 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References