288113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 32101..32620 Replicon plasmid 4
Accession NZ_LR135281
Organism Enterococcus faecium isolate E6975

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag EQB65_RS17020 Protein ID WP_000588503.1
Coordinates 32363..32620 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag EQB65_RS17015 Protein ID WP_000388479.1
Coordinates 32101..32370 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB65_RS16980 27886..28302 - 417 WP_001232859.1 hypothetical protein -
EQB65_RS16985 28305..28589 - 285 WP_000353844.1 hypothetical protein -
EQB65_RS16990 29289..29384 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
EQB65_RS16995 30088..30768 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
EQB65_RS17000 30844..31410 + 567 Protein_35 hypothetical protein -
EQB65_RS17010 31791..31970 + 180 WP_001120991.1 hypothetical protein -
EQB65_RS17015 32101..32370 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB65_RS17020 32363..32620 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
EQB65_RS17570 33079..33222 + 144 WP_164857621.1 hypothetical protein -
EQB65_RS17025 33257..34081 + 825 WP_001809248.1 hypothetical protein -
EQB65_RS17030 34246..34860 - 615 WP_001261742.1 recombinase family protein -
EQB65_RS17035 35310..36635 + 1326 WP_000969590.1 Y-family DNA polymerase -
EQB65_RS17040 36628..36978 + 351 WP_000568378.1 hypothetical protein -
EQB65_RS17045 36975..37154 + 180 WP_001021554.1 hypothetical protein -
EQB65_RS17050 37290..37580 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..39397 39397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T288113 WP_000588503.1 NZ_LR135281:32363-32620 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT288113 WP_000388479.1 NZ_LR135281:32101-32370 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References