288047

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 174496..175025 Replicon chromosome
Accession NZ_LR135179
Organism Enterococcus faecium isolate E0595

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag EL352_RS00915 Protein ID WP_002294198.1
Coordinates 174759..175025 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag EL352_RS00910 Protein ID WP_002294199.1
Coordinates 174496..174759 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL352_RS00895 171871..173694 + 1824 WP_002328658.1 APC family permease -
EL352_RS00900 173836..174021 - 186 WP_002294201.1 hypothetical protein -
EL352_RS00910 174496..174759 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL352_RS00915 174759..175025 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
EL352_RS00920 175226..175714 + 489 WP_002328659.1 hypothetical protein -
EL352_RS00925 176256..176927 - 672 WP_002319469.1 ABC transporter permease -
EL352_RS00930 176924..177841 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
EL352_RS00935 177838..178479 - 642 WP_002293405.1 ABC transporter permease -
EL352_RS00940 178483..179658 - 1176 WP_002328660.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T288047 WP_002294198.1 NZ_LR135179:174759-175025 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT288047 WP_002294199.1 NZ_LR135179:174496-174759 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References