Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 74323..74863 | Replicon | plasmid 11 |
Accession | NZ_LR134420 | ||
Organism | Legionella adelaidensis strain NCTC12735 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A0W0R3R8 |
Locus tag | EL206_RS03665 | Protein ID | WP_058461456.1 |
Coordinates | 74323..74643 (-) | Length | 107 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A0W0R3U5 |
Locus tag | EL206_RS03670 | Protein ID | WP_058461455.1 |
Coordinates | 74630..74863 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EL206_RS03635 | 69383..69892 | + | 510 | WP_058461462.1 | lipopolysaccharide transport periplasmic protein LptA | - |
EL206_RS03640 | 69889..70614 | + | 726 | WP_058461461.1 | LPS export ABC transporter ATP-binding protein | - |
EL206_RS03645 | 70623..71201 | + | 579 | WP_058461460.1 | aminodeoxychorismate/anthranilate synthase component II | - |
EL206_RS03650 | 71185..72189 | + | 1005 | WP_058461459.1 | anthranilate phosphoribosyltransferase | - |
EL206_RS03655 | 72190..72954 | + | 765 | WP_058461458.1 | indole-3-glycerol phosphate synthase TrpC | - |
EL206_RS03660 | 73230..74204 | + | 975 | WP_058461457.1 | glutaminase A | - |
EL206_RS03665 | 74323..74643 | - | 321 | WP_058461456.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
EL206_RS03670 | 74630..74863 | - | 234 | WP_058461455.1 | hypothetical protein | Antitoxin |
EL206_RS03675 | 75012..75311 | + | 300 | WP_058461454.1 | hypothetical protein | - |
EL206_RS03680 | 75281..75547 | + | 267 | WP_084758816.1 | GNAT family N-acetyltransferase | - |
EL206_RS09955 | 75751..75900 | - | 150 | WP_165476678.1 | hypothetical protein | - |
EL206_RS03685 | 76078..77457 | + | 1380 | WP_058461452.1 | L-serine ammonia-lyase | - |
EL206_RS03690 | 77487..78269 | + | 783 | WP_162261866.1 | hypothetical protein | - |
EL206_RS03695 | 78572..79534 | + | 963 | WP_058461450.1 | IS110 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..188989 | 188989 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 15765.91 Da Isoelectric Point: 5.5500
>T287875 WP_058461456.1 NZ_LR134420:c74643-74323 [Legionella adelaidensis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 321 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0W0R3R8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0W0R3U5 |