Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 74323..74863 Replicon plasmid 11
Accession NZ_LR134420
Organism Legionella adelaidensis strain NCTC12735

Toxin (Protein)


Gene name mazF Uniprot ID A0A0W0R3R8
Locus tag EL206_RS03665 Protein ID WP_058461456.1
Coordinates 74323..74643 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0W0R3U5
Locus tag EL206_RS03670 Protein ID WP_058461455.1
Coordinates 74630..74863 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL206_RS03635 69383..69892 + 510 WP_058461462.1 lipopolysaccharide transport periplasmic protein LptA -
EL206_RS03640 69889..70614 + 726 WP_058461461.1 LPS export ABC transporter ATP-binding protein -
EL206_RS03645 70623..71201 + 579 WP_058461460.1 aminodeoxychorismate/anthranilate synthase component II -
EL206_RS03650 71185..72189 + 1005 WP_058461459.1 anthranilate phosphoribosyltransferase -
EL206_RS03655 72190..72954 + 765 WP_058461458.1 indole-3-glycerol phosphate synthase TrpC -
EL206_RS03660 73230..74204 + 975 WP_058461457.1 glutaminase A -
EL206_RS03665 74323..74643 - 321 WP_058461456.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL206_RS03670 74630..74863 - 234 WP_058461455.1 hypothetical protein Antitoxin
EL206_RS03675 75012..75311 + 300 WP_058461454.1 hypothetical protein -
EL206_RS03680 75281..75547 + 267 WP_084758816.1 GNAT family N-acetyltransferase -
EL206_RS09955 75751..75900 - 150 WP_165476678.1 hypothetical protein -
EL206_RS03685 76078..77457 + 1380 WP_058461452.1 L-serine ammonia-lyase -
EL206_RS03690 77487..78269 + 783 WP_162261866.1 hypothetical protein -
EL206_RS03695 78572..79534 + 963 WP_058461450.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188989 188989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 15765.91 Da        Isoelectric Point: 5.5500

>T287875 WP_058461456.1 NZ_LR134420:c74643-74323 [Legionella adelaidensis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 321 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 11497.79 Da        Isoelectric Point: 5.5500

>AT287875 WP_058461455.1 NZ_LR134420:c74863-74630 [Legionella adelaidensis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0R3R8

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0R3U5

References