287841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2678655..2679895 Replicon chromosome
Accession NZ_LR134380
Organism Legionella pneumophila subsp. pascullei strain NCTC12273

Toxin (Protein)


Gene name HipT Uniprot ID A0A140J6I8
Locus tag EL201_RS12040 Protein ID WP_027222482.1
Coordinates 2678960..2679895 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A140J6I7
Locus tag EL201_RS12035 Protein ID WP_027222481.1
Coordinates 2678655..2678963 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL201_RS12000 2674127..2674987 + 861 WP_011947276.1 DUF2608 domain-containing protein -
EL201_RS12005 2675337..2675636 - 300 WP_027222477.1 hypothetical protein -
EL201_RS12010 2675647..2675958 - 312 WP_011947278.1 cupin -
EL201_RS12015 2675949..2676230 - 282 WP_050598290.1 hypothetical protein -
EL201_RS12020 2676406..2676879 + 474 WP_027222478.1 hypothetical protein -
EL201_RS12025 2677069..2677986 + 918 WP_027222479.1 LysR family transcriptional regulator -
EL201_RS12030 2678431..2678658 + 228 WP_027222480.1 helix-turn-helix transcriptional regulator -
EL201_RS12035 2678655..2678963 + 309 WP_027222481.1 HipA N-terminal domain-containing protein Antitoxin
EL201_RS12040 2678960..2679895 + 936 WP_027222482.1 HipA domain-containing protein Toxin
EL201_RS12050 2680197..2681342 + 1146 WP_027222483.1 hypothetical protein -
EL201_RS12055 2681352..2682539 - 1188 WP_061773169.1 fatty acid desaturase -
EL201_RS12060 2682664..2682831 - 168 WP_011214444.1 DUF3309 domain-containing protein -
EL201_RS15700 2682943..2683116 + 174 WP_158272786.1 hypothetical protein -
EL201_RS12065 2683288..2683644 + 357 WP_027222484.1 hypothetical protein -
EL201_RS12070 2683685..2684617 - 933 WP_027222485.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 36037.79 Da        Isoelectric Point: 9.3028

>T287841 WP_027222482.1 NZ_LR134380:2678960-2679895 [Legionella pneumophila subsp. pascullei]
MKRCPITYERISDQENYSQRGLYLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSANLKIKEGCFEIVDQNG
HYILKPQSDVYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIEVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQKIIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKQLNFF

Download         Length: 936 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11664.54 Da        Isoelectric Point: 4.7719

>AT287841 WP_027222481.1 NZ_LR134380:2678655-2678963 [Legionella pneumophila subsp. pascullei]
MRKAYVSVNGIKAGILEELQGGKYQFTYFDDYQGAPVSLTMPLKNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLIIVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140J6I8

Antitoxin

Source ID Structure
AlphaFold DB A0A140J6I7

References