Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1759331..1759967 Replicon chromosome
Accession NZ_LR134354
Organism Bifidobacterium longum subsp. infantis strain NCTC11817

Toxin (Protein)


Gene name mazF Uniprot ID W6EZW1
Locus tag EL189_RS08775 Protein ID WP_014484977.1
Coordinates 1759611..1759967 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D6PAX1
Locus tag EL189_RS08770 Protein ID WP_012577921.1
Coordinates 1759331..1759624 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL189_RS08745 1754403..1754858 - 456 WP_012577916.1 Holliday junction resolvase RuvX -
EL189_RS08750 1754867..1757545 - 2679 WP_012577917.1 alanine--tRNA ligase -
EL189_RS13820 1757674..1757910 - 237 WP_012577918.1 hypothetical protein -
EL189_RS08760 1757910..1758308 - 399 WP_012577919.1 DUF948 domain-containing protein -
EL189_RS08765 1758391..1759074 - 684 WP_012577920.1 histidine phosphatase family protein -
EL189_RS08770 1759331..1759624 + 294 WP_012577921.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL189_RS08775 1759611..1759967 + 357 WP_014484977.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL189_RS08780 1760144..1760746 - 603 WP_012577923.1 transglutaminase family protein -
EL189_RS08785 1760851..1761207 - 357 WP_012577924.1 SdpI family protein -
EL189_RS08790 1761300..1761740 + 441 WP_012577925.1 cytidine deaminase -
EL189_RS08795 1761923..1762705 + 783 WP_012577926.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
EL189_RS08800 1762884..1763510 - 627 WP_007052130.1 30S ribosomal protein S4 -
EL189_RS08805 1763709..1764701 - 993 WP_012577927.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-53)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13302.25 Da        Isoelectric Point: 8.9603

>T287799 WP_014484977.1 NZ_LR134354:1759611-1759967 [Bifidobacterium longum subsp. infantis]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA

Download         Length: 357 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10866.31 Da        Isoelectric Point: 4.2896

>AT287799 WP_012577921.1 NZ_LR134354:1759331-1759624 [Bifidobacterium longum subsp. infantis]
MAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7D489

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2VTZ6

References