Detailed information of TA system TA287755

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 2472083..2472306
• Replicon: chromosome
• Accession: NZ_LR134340
• Organism: Escherichia marmotae strain NCTC11133

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A7H9K3A2
• Locus tag: EL192_RS11890
• Protein ID: WP_032141347.1
• Coordinates: 2472199..2472306 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2472083..2472149 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL192_RS11865	2467363..2468757	-	1395	WP_016248766.1	YchO/YchP family invasin	-
EL192_RS11870	2468941..2469294	+	354	WP_001169672.1	DsrE/F sulfur relay family protein YchN	-
EL192_RS11875	2469338..2470033	-	696	WP_016248767.1	glutathione-specific gamma-glutamylcyclotransferase	-
EL192_RS11880	2470191..2470421	-	231	WP_001146437.1	putative cation transport regulator ChaB	-
EL192_RS11885	2470690..2471790	+	1101	WP_001516524.1	sodium-potassium/proton antiporter ChaA	-
-	2472083..2472149	-	67	-	-	Antitoxin
EL192_RS11890	2472199..2472306	+	108	WP_032141347.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
EL192_RS11895	2472486..2473340	-	855	WP_000811071.1	3-deoxy-8-phosphooctulonate synthase	-
EL192_RS11900	2473376..2474185	-	810	WP_016248768.1	invasion regulator SirB1	-
EL192_RS11905	2474189..2474581	-	393	WP_000200357.1	invasion regulator SirB2	-
EL192_RS11910	2474578..2475411	-	834	WP_000456440.1	peptide chain release factor N(5)-glutamine methyltransferase	-
EL192_RS11915	2475411..2476493	-	1083	WP_000804714.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3953.71 Da
• Isoelectric Point: 11.4779

>T287755 WP_032141347.1 NZ_LR134340:2472199-2472306 [Escherichia marmotae]
MTLAQFAITFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 67 bp

>AT287755 NZ_LR134340:c2472149-2472083 [Escherichia marmotae]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7H9K3A2

Antitoxin