Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 2742936..2743520 Replicon chromosome
Accession NZ_LR134335
Organism Yersinia enterocolitica subsp. palearctica strain NCTC13769

Toxin (Protein)


Gene name ypjF Uniprot ID A0A7U7ISC5
Locus tag EL202_RS13010 Protein ID WP_005165296.1
Coordinates 2742936..2743304 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EL202_RS13015 Protein ID WP_129019424.1
Coordinates 2743368..2743520 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL202_RS12990 2738143..2739063 + 921 WP_005165286.1 ROK family protein -
EL202_RS12995 2739148..2740110 + 963 WP_005165289.1 LacI family transcriptional regulator -
EL202_RS13000 2740144..2740617 - 474 WP_005165291.1 GNAT family N-acetyltransferase -
EL202_RS13005 2741853..2742707 - 855 WP_005165294.1 DUF4942 domain-containing protein -
EL202_RS13010 2742936..2743304 - 369 WP_005165296.1 TA system toxin CbtA family protein Toxin
EL202_RS13015 2743368..2743520 - 153 WP_129019424.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL202_RS13020 2743589..2744791 + 1203 WP_005178352.1 IS256 family transposase -
EL202_RS13025 2744966..2746429 + 1464 WP_005166182.1 alpha/beta hydrolase -
EL202_RS13030 2746662..2748068 - 1407 WP_005166180.1 filamentous hemagglutinin N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2743589..2744791 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(1-45)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13609.55 Da        Isoelectric Point: 6.4731

>T287733 WP_005165296.1 NZ_LR134335:c2743304-2742936 [Yersinia enterocolitica subsp. palearctica]
MQTLPVTSKRAAYACLSPVIVWQSMLTYLLEQHYGLVLSDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLARTDHRGF
SCQEQSPFITSIDILRARRATGLMTRMGYQTITSVIRGGKQA

Download         Length: 369 bp

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5593.44 Da        Isoelectric Point: 4.5803

>AT287733 WP_129019424.1 NZ_LR134335:c2743520-2743368 [Yersinia enterocolitica subsp. palearctica]
MELMLLSGELNPRYQHCVTLYRNGLICEADSLGSQGYVYLAIYPTPQSIA

Download         Length: 153 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7ISC5

Antitoxin

Source ID Structure

References