Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2681786..2682429 Replicon chromosome
Accession NZ_LR134335
Organism Yersinia enterocolitica subsp. palearctica strain NCTC13769

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag EL202_RS12755 Protein ID WP_005161957.1
Coordinates 2682010..2682429 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag EL202_RS12750 Protein ID WP_005161959.1
Coordinates 2681786..2682013 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL202_RS12725 2676899..2678062 + 1164 WP_005161974.1 mannitol-1-phosphate 5-dehydrogenase -
EL202_RS12730 2678294..2678848 + 555 WP_005161972.1 MltR family transcriptional regulator -
EL202_RS12735 2678845..2679456 - 612 WP_016266331.1 LysE family translocator -
EL202_RS12740 2679724..2681205 + 1482 WP_005161967.1 PLP-dependent aminotransferase family protein -
EL202_RS12745 2681298..2681654 + 357 WP_005161962.1 YibL family ribosome-associated protein -
EL202_RS12750 2681786..2682013 + 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL202_RS12755 2682010..2682429 + 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
EL202_RS12760 2682583..2683254 - 672 WP_014609259.1 6-N-hydroxylaminopurine resistance protein -
EL202_RS12765 2683333..2685282 - 1950 WP_005161951.1 methyl-accepting chemotaxis protein -
EL202_RS12770 2685606..2686229 - 624 WP_005161946.1 superoxide dismutase [Mn] -
EL202_RS12775 2686356..2687210 - 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T287732 WP_005161957.1 NZ_LR134335:2682010-2682429 [Yersinia enterocolitica subsp. palearctica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT287732 WP_005161959.1 NZ_LR134335:2681786-2682013 [Yersinia enterocolitica subsp. palearctica]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References