Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2130306..2131935 Replicon chromosome
Accession NZ_LR134335
Organism Yersinia enterocolitica subsp. palearctica strain NCTC13769

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U7IQ60
Locus tag EL202_RS10315 Protein ID WP_005165219.1
Coordinates 2130607..2131935 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A7U7FJW4
Locus tag EL202_RS10310 Protein ID WP_005165217.1
Coordinates 2130306..2130605 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL202_RS10295 2125748..2127397 - 1650 WP_005165210.1 Na+/H+ antiporter -
EL202_RS10300 2127612..2128979 - 1368 WP_005165212.1 NCS2 family permease -
EL202_RS10305 2129340..2130011 - 672 WP_005165214.1 glutathione S-transferase -
EL202_RS10310 2130306..2130605 + 300 WP_005165217.1 helix-turn-helix transcriptional regulator Antitoxin
EL202_RS10315 2130607..2131935 + 1329 WP_005165219.1 type II toxin-antitoxin system HipA family toxin Toxin
EL202_RS10320 2132024..2132572 - 549 WP_005165221.1 single-stranded DNA-binding protein SSB1 -
EL202_RS10325 2133101..2135932 + 2832 WP_005165223.1 excinuclease ABC subunit UvrA -
EL202_RS10330 2135991..2136344 - 354 WP_005165225.1 MmcQ/YjbR family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49925.93 Da        Isoelectric Point: 6.8736

>T287731 WP_005165219.1 NZ_LR134335:2130607-2131935 [Yersinia enterocolitica subsp. palearctica]
MARRIQRLNIWMNGQHVGYWEKNRGEESLVYAQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSINPFDLLFELGRDCVGAIQLLTDDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVRPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVASCEIGQFEDQKALIVERF
DRRLSRDKSWIVRLPQEDMCQATGTSPLKKYQMDGGPSITTIMEILSGSDNASEDRNVFFKAQIIFWLLAATDGHAKNFS
IAHLPGSRYHLTPLYDVLSTHPIIGSGRNQIAVQKSKLAMAVRGSKNYYLINQIQRRHWRKQAEFVGLGAIQADTIIDEI
IAATPRVITQVQAQLPANFPADLAEKILTGLHKQCEKISAML

Download         Length: 1329 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11141.78 Da        Isoelectric Point: 8.5374

>AT287731 WP_005165217.1 NZ_LR134335:2130306-2130605 [Yersinia enterocolitica subsp. palearctica]
MDYPIKILSQLRPTLIGFRKNKGLTQASLAQLLGITQQSYAKLEADPTSASVERLFKVLQLLDVELILSEKKNASAHPNK
THQPEQSQTIDLPSKQEDW

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IQ60

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJW4

References