Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2046374..2046957 Replicon chromosome
Accession NZ_LR134335
Organism Yersinia enterocolitica subsp. palearctica strain NCTC13769

Toxin (Protein)


Gene name higB Uniprot ID A0A7U7FJS5
Locus tag EL202_RS09935 Protein ID WP_005162526.1
Coordinates 2046374..2046652 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL202_RS09940 Protein ID WP_005162529.1
Coordinates 2046652..2046957 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL202_RS09915 2041855..2042802 - 948 WP_005162520.1 trehalose operon repressor TreR -
EL202_RS09930 2043574..2046294 + 2721 WP_005162523.1 magnesium-translocating P-type ATPase -
EL202_RS09935 2046374..2046652 + 279 WP_005162526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL202_RS09940 2046652..2046957 + 306 WP_005162529.1 HigA family addiction module antidote protein Antitoxin
EL202_RS09945 2047029..2048957 - 1929 WP_005162532.1 BglG family transcription antiterminator -
EL202_RS09950 2049030..2050271 - 1242 WP_005162536.1 lactonase family protein -
EL202_RS09955 2050401..2051141 - 741 Protein_1885 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10694.10 Da        Isoelectric Point: 7.4011

>T287730 WP_005162526.1 NZ_LR134335:2046374-2046652 [Yersinia enterocolitica subsp. palearctica]
MIKSWKHKGLQRFFETGSAAGINPQHVKRIRDRLRFIDLAETIEDVNVAGYKLHPLQGEREGIWSVTVSGNWRITFEFTA
GDAFILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10934.77 Da        Isoelectric Point: 6.7158

>AT287730 WP_005162529.1 NZ_LR134335:2046652-2046957 [Yersinia enterocolitica subsp. palearctica]
MKMHNPPHPGEMIEGILEDLGLGIREFARALNVSPSTVQRLVACKAAISPEMAVKLAAVLGSTPAMWLRLQAAYDLGKAE
ENVDVSNLTKLYKPDPISLHS

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FJS5

Antitoxin

Source ID Structure

References