Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 6544532..6545790 Replicon chromosome
Accession NZ_LR134330
Organism Pseudomonas aeruginosa strain NCTC13715

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag EL342_RS31190 Protein ID WP_003086331.1
Coordinates 6544532..6545287 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag EL342_RS31195 Protein ID WP_003086329.1
Coordinates 6545422..6545790 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL342_RS31180 6539703..6542246 + 2544 WP_033939237.1 acyl-homoserine-lactone acylase QuiP -
EL342_RS31185 6542401..6543762 - 1362 WP_003081943.1 DNA recombination protein RmuC -
EL342_RS31190 6544532..6545287 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
EL342_RS31195 6545422..6545790 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
EL342_RS31200 6545863..6547149 - 1287 WP_033939236.1 FAD-binding oxidoreductase -
EL342_RS31205 6547205..6548794 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
EL342_RS31210 6548873..6549349 + 477 WP_003140638.1 hypothetical protein -
EL342_RS32595 6549352..6549627 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T287703 WP_003086331.1 NZ_LR134330:c6545287-6544532 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT287703 WP_003086329.1 NZ_LR134330:c6545790-6545422 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References