Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 412856..414444 Replicon chromosome
Accession NZ_LR134321
Organism Shewanella baltica strain NCTC10737

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL185_RS01935 Protein ID WP_126491018.1
Coordinates 413137..414444 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL185_RS01930 Protein ID WP_126491017.1
Coordinates 412856..413137 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL185_RS01910 408494..409390 - 897 WP_126491014.1 LysR family transcriptional regulator -
EL185_RS01915 409628..410364 + 737 Protein_361 pyrimidine 5'-nucleotidase -
EL185_RS01920 410399..411037 - 639 WP_126491015.1 multidrug MFS transporter -
EL185_RS01925 411219..412352 + 1134 WP_126491016.1 hypothetical protein -
EL185_RS01930 412856..413137 + 282 WP_126491017.1 helix-turn-helix domain-containing protein Antitoxin
EL185_RS01935 413137..414444 + 1308 WP_126491018.1 type II toxin-antitoxin system HipA family toxin Toxin
EL185_RS01940 414718..415041 - 324 WP_126491019.1 hypothetical protein -
EL185_RS01945 415188..416051 - 864 WP_006086670.1 YicC family protein -
EL185_RS01950 416461..417174 + 714 WP_006079862.1 ribonuclease PH -
EL185_RS01955 417351..417992 + 642 WP_006079863.1 orotate phosphoribosyltransferase -
EL185_RS01960 418218..418868 - 651 WP_006079864.1 GTP cyclohydrolase I FolE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48603.14 Da        Isoelectric Point: 7.5317

>T287667 WP_126491018.1 NZ_LR134321:413137-414444 [Shewanella baltica]
MAVLDVYMNGYLVGELTKSSTGSHQFAYAQQWLAIPGSRPISLSMPLRKQAYKGDEVYNFFDNLLPDNHEVKNRVVARHN
ADSTQAFDLLAKIGQDSVGALQLVPHGQPPFDTKKIESKPLSDKQLEKVLKGYQSNIPLGMLADDDDFRISIAGAQEKTA
LLKLNGEWRLPIKSTPTTHIIKLPIGEINSHSHSIDMSDSVENEYLCMMIVREFGLDAPQCSIIKVGDIKALAVERFDRR
LSSDGTWIMRLPQEDFCQALNIPPAKKYESLGGPGIEQIMPYLLGSMNSERDRYNFIKSQVLFWLLAATDGHAKNFSLFI
EADGGYRLTPFYDILSMYPVIGGKGLNIRDAKLAMGLKAAKGKKYQINQIFPRHFILTAKAVGFDTGIMMEMMRDIADKV
EAVVVKVKAQLPDDFPPHIQDSILNGLTDRIKRIA

Download         Length: 1308 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.16 Da        Isoelectric Point: 7.0147

>AT287667 WP_126491017.1 NZ_LR134321:412856-413137 [Shewanella baltica]
MKVTNAKQLSTYLKDARLNAQLSQSKVASKVGIRQDTVSSFELNPDSTKLETLFKILSALNLELDIKVRNLQLVDERRHD
NATVPEQEWKEEW

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References