Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6555500..6556095 Replicon chromosome
Accession NZ_LR134308
Organism Pseudomonas aeruginosa strain NCTC11445

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL295_RS31775 Protein ID WP_071537327.1
Coordinates 6555500..6555778 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL295_RS31780 Protein ID WP_003113527.1
Coordinates 6555790..6556095 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL295_RS31755 6550926..6552164 + 1239 WP_014603324.1 C69 family dipeptidase -
EL295_RS31760 6552226..6552873 + 648 WP_003095021.1 carbonate dehydratase -
EL295_RS31765 6552943..6555171 - 2229 WP_021264080.1 TonB-dependent receptor -
EL295_RS31775 6555500..6555778 + 279 WP_071537327.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL295_RS31780 6555790..6556095 + 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
EL295_RS31790 6556501..6557601 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
EL295_RS31795 6557642..6558226 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
EL295_RS31800 6558268..6558882 - 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
EL295_RS31805 6558999..6559940 - 942 WP_124135336.1 ribose-phosphate pyrophosphokinase -
EL295_RS31815 6560107..6560955 - 849 WP_126453433.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T287582 WP_071537327.1 NZ_LR134308:6555500-6555778 [Pseudomonas aeruginosa]
MILTFRCDEARQLFETGLSRRWGAILTVATRKLTMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT287582 WP_003113527.1 NZ_LR134308:6555790-6556095 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References