Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 502756..503437 Replicon chromosome
Accession NZ_LR134308
Organism Pseudomonas aeruginosa strain NCTC11445

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag EL295_RS02390 Protein ID WP_003111825.1
Coordinates 502756..503121 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag EL295_RS02395 Protein ID WP_003159602.1
Coordinates 503114..503437 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL295_RS02360 498737..499171 - 435 WP_003116494.1 RidA family protein -
EL295_RS02365 499392..500345 + 954 WP_003085661.1 LysR family transcriptional regulator -
EL295_RS02370 500318..501202 - 885 WP_033974362.1 LysR family transcriptional regulator -
EL295_RS02375 501303..501728 + 426 WP_003114206.1 ring-cleaving dioxygenase -
EL295_RS02380 501747..502019 - 273 WP_003085667.1 hypothetical protein -
EL295_RS02385 502226..502465 + 240 WP_049876884.1 hypothetical protein -
EL295_RS02390 502756..503121 + 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL295_RS02395 503114..503437 + 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
EL295_RS02400 503813..504901 - 1089 WP_003145732.1 DUF3396 domain-containing protein -
EL295_RS02405 504918..505619 - 702 WP_033974360.1 VRR-NUC domain-containing protein -
EL295_RS02410 505616..506134 - 519 WP_010793873.1 PAAR domain-containing protein -
EL295_RS02415 506308..506643 - 336 WP_003119438.1 TM2 domain-containing protein -
EL295_RS02420 506886..507524 - 639 WP_003145727.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 501303..559354 58051


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T287575 WP_003111825.1 NZ_LR134308:502756-503121 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT287575 WP_003159602.1 NZ_LR134308:503114-503437 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References