Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3312460..3313078 Replicon chromosome
Accession NZ_LR134239
Organism Escherichia coli strain NCTC9100

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL124_RS16165 Protein ID WP_001291435.1
Coordinates 3312860..3313078 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL124_RS16160 Protein ID WP_000344800.1
Coordinates 3312460..3312834 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL124_RS16150 3307549..3308742 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL124_RS16155 3308765..3311914 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EL124_RS16160 3312460..3312834 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL124_RS16165 3312860..3313078 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL124_RS16170 3313250..3313801 + 552 WP_000102564.1 maltose O-acetyltransferase -
EL124_RS16175 3313917..3314387 + 471 WP_000136192.1 YlaC family protein -
EL124_RS16180 3314551..3316101 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL124_RS16185 3316143..3316496 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EL124_RS16195 3316875..3317186 + 312 WP_000409911.1 MGMT family protein -
EL124_RS16200 3317217..3317789 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T287318 WP_001291435.1 NZ_LR134239:3312860-3313078 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT287318 WP_000344800.1 NZ_LR134239:3312460-3312834 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References