Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 46923..47714 Replicon chromosome
Accession NZ_LR134237
Organism Escherichia coli strain NCTC9022

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag EL138_RS00240 Protein ID WP_000691791.1
Coordinates 46923..47348 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L1KVZ6
Locus tag EL138_RS00245 Protein ID WP_000939437.1
Coordinates 47379..47714 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL138_RS00210 42589..43086 - 498 WP_000509808.1 hypothetical protein -
EL138_RS00220 43768..44154 - 387 WP_001270938.1 DUF2441 domain-containing protein -
EL138_RS00225 44777..45508 - 732 WP_001216639.1 TIGR02646 family protein -
EL138_RS00230 45505..45726 - 222 WP_126125326.1 hypothetical protein -
EL138_RS00235 45711..46902 - 1192 Protein_45 AAA family ATPase -
EL138_RS00240 46923..47348 - 426 WP_000691791.1 TA system toxin CbtA family protein Toxin
EL138_RS00245 47379..47714 - 336 WP_000939437.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL138_RS00250 47714..48187 - 474 WP_001292742.1 DNA repair protein RadC -
EL138_RS00255 48217..49035 - 819 WP_000761990.1 DUF945 domain-containing protein -
EL138_RS00260 49271..50224 - 954 WP_000290406.1 hypothetical protein -
EL138_RS00265 50817..51431 + 615 WP_000772910.1 inovirus Gp2 family protein -
EL138_RS00270 51549..51767 + 219 WP_000070772.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 44777..68712 23935


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16490.11 Da        Isoelectric Point: 10.2376

>T287283 WP_000691791.1 NZ_LR134237:c47348-46923 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVNAVNFLVEKYELVRIDRKGF
SWQEQTPYLRAVDILRARQATGLRIQCKNTNIISRMADSRHDKRLYQRTFKACKRCYYTKT

Download         Length: 426 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12556.56 Da        Isoelectric Point: 7.6977

>AT287283 WP_000939437.1 NZ_LR134237:c47714-47379 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3L1KVZ6

References