Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2350289..2350927 Replicon chromosome
Accession NZ_LR134231
Organism Escherichia coli strain NCTC9087

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL105_RS11475 Protein ID WP_000813794.1
Coordinates 2350751..2350927 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL105_RS11470 Protein ID WP_001270286.1
Coordinates 2350289..2350705 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL105_RS11450 2345441..2346382 - 942 WP_001251304.1 ABC transporter permease -
EL105_RS11455 2346383..2347396 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
EL105_RS11460 2347414..2348559 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
EL105_RS11465 2348804..2350210 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
EL105_RS11470 2350289..2350705 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL105_RS11475 2350751..2350927 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL105_RS11480 2351149..2351379 + 231 WP_000494244.1 YncJ family protein -
EL105_RS11485 2351471..2353432 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL105_RS11490 2353505..2354041 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
EL105_RS11495 2354094..2355308 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2355348..2356496 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T287219 WP_000813794.1 NZ_LR134231:c2350927-2350751 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT287219 WP_001270286.1 NZ_LR134231:c2350705-2350289 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References