287136

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3494520..3495357 Replicon chromosome
Accession NZ_LR134222
Organism Escherichia coli strain NCTC11129

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag EL113_RS17175 Protein ID WP_000227784.1
Coordinates 3494815..3495357 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag EL113_RS17170 Protein ID WP_001297137.1
Coordinates 3494520..3494831 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL113_RS17145 3489540..3490487 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
EL113_RS17150 3490509..3492500 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
EL113_RS17155 3492490..3493104 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
EL113_RS17160 3493104..3493433 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
EL113_RS17165 3493445..3494335 + 891 WP_000971336.1 heme o synthase -
EL113_RS17170 3494520..3494831 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
EL113_RS17175 3494815..3495357 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
EL113_RS17180 3495413..3496348 - 936 WP_001297127.1 sel1 repeat family protein -
EL113_RS17185 3496756..3498120 + 1365 WP_001000978.1 MFS transporter -
EL113_RS17190 3498248..3498739 - 492 WP_001138904.1 nucleotide binding protein YajQ -
EL113_RS17195 3498907..3499818 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T287136 WP_000227784.1 NZ_LR134222:3494815-3495357 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT287136 WP_001297137.1 NZ_LR134222:3494520-3494831 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References